Andrew J. Grosovsky
Professor of Cell Biology and Toxicologist
|
Biomedical Research
Ph.D., Harvard University, 1982
VOICE: 951-827-3193 |
Research in my laboratory focuses on the mechanisms of mutagenesis and genetic instability in human cells. Genetic instability is the subject of much recent attention as its role in tumor progression has become increasingly clear. We are characterizing the molecular basis for chromosomal breakage hotspots occurring in heterochromatic regions of several human chromosomes. Breakage at these regions can lead to chromosomal instability in genetically susceptible cells. These efforts are integrated with studies describing the DNA sequence alterations which occur following exposure to environmental mutagens. The spectrum of mutations is highly specific and characteristic for each agent. This "mutational fingerprint" may permit the retrospective identification of environmental carcinogen exposure responsible for induction of specific tumors in human populations.
SELECTED PUBLICATIONS
Pongsaensook, P., Smith, L.E. and Grosovsky, A.J. Isolation of an APRT heterozygote from TK6 human lymphoblasts: Predominance of multi-locus loss of heterozygosity among spontaneous APRT mutants. Mutation Res. 377:27-36 (1997).
Giver, C.R. and Grosovsky A. J. Single and coincident intragenic mutations attributable to gene conversion in a human cell line. Genetics 146:1429-1439 (1997).
Nelson, S., K. Parks and A. Grosovsky. Ionizing radiation signature mutations in human cell mutants induced by low dose exposures. Mutagenesis 11:275-279 (1996).
Grosovsky, A.J., Parks, K., Giver, C. and Nelson, S. Clonal analysis of delayed karyotypic abnormalities and gene mutations in radiation induced genetic instability. Molecular and Cellular Biology 16:6252-6262 (1996).